Our research is focused on the elucidation of the molecular mechanisms of transcriptional regulation. We use single molecule techniques such as the tethered particle motion technique (TPM), magnetic tweezers (MT), atomic force microscopy (AFM) and single molecule fluorescence together with more traditional biochemical and biomolecular techniques. We develop instrumentation and computational analyses as needed to carry out our investigations. Our research interests span loop-based genetic switches, transcription roadblocks, the interplay between transcription and DNA supercoiling, topoisomerases and DNA mechanics.
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Sep 20, 2022 - Jin's manuscript "A Thermodynamic Model of Bacterial Transcription" is accepted by PRE
Jul 12, 2022 - Laura gave a lecture at the International School of physics "Enrico Fermi".
June, 2022 - The Anerican Institute of Physics Society of Physics Students selected Allison to go to the Physics Congress in Washington DC (Oct 6-8).
June, 2022 - Allison Cartee receives a summer fellowship from the American Society of Physicists in Medicine to join Dr. Sgouros' research group at Johns Hopkins.
Apr 20, 2022 - Laura gave a talk in The Living Histories series!
Apr 1, 2022 - Anna successfully defended her thesis and received high honors!
Mar 2, 2022 - Yue presented a talk "Proteins mediating different DNA topologies block RNAP elongation with different efficiency" at BPS! Laura, David and Jin also presented three posters at BPS!
Feb 17, 2022 - Wenxuan & Yan's paper on "Positive supercoiling favors transcription elongation through lac repressor-mediated DNA loops" has been published by Nucleic Acids Research. DOI: 10.1063/10.0006622
Dec 03, 2021 - Wenxuan successfully defended her PhD dissertation and is now Dr. Xu! Congratulation, Wenxuan!
Oct 20, 2021 - Our review on "Single-molecule insights into torsion and roadblocks in bacterial transcript elongation" has been published on journal "transcription", check that out!
Oct 19, 2021 - Our article in the Journal of Applied Physics was featured in SciLight!!! DOI: 10.1063/10.0006622
Oct 18, 2021 - Allison Published an article "A Physical Perspective on Molecular Biology" on Science News. Congratulations, Allison! Find the article here!